Research Article
Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population
Table 2
Distribution of SNPs in IL-31 among the cases and controls and their association with the epithelial ovarian cancer.
| | rs7977932 | | rs4758680 | | Case, (%) | Control, (%) | OR (95% CI) | value | | Case, (%) | Control, (%) | OR (95% CI) | value |
| | Model | Genotype | | | | | Genotype | | | | | | Codominant | CC | 368 (89.3%) | 351 (82%) | 1.00 | | CC | 252 (61.2%) | 297 (69.4%) | 1.00 | | | CG | 41 (9.9%) | 72 (16.8%) | 0.54 (0.36–0.82) | 0.01 | CA | 141 (34.2%) | 114 (26.6%) | 1.45 (1.09–1.96) | 0.042 | | GG | 3 (0.7%) | 5 (1.2%) | 0.57 (0.14–2.44) | | AA | 19 (4.6%) | 17 (4%) | 1.32 (0.67–2.56) | | | Dominant | CC | 368 (89.3%) | 351 (82%) | 1.00 | | CC | 252 (61.2%) | 297 (69.4%) | 1.00 | | | CG/GG | 44 (10.7%) | 77 (18%) | 0.55 (0.37–0.81) | 0.0024 | CA/AA | 160 (38.8%) | 131 (30.6%) | 1.45 (1.09–1.92) | 0.012 | | Recessive | CC/CG | 409 (99.3%) | 423 (98.8%) | 1.00 | | CC/CA | 393 (95.4%) | 411 (96%) | 1.00 | | | GG | 3 (0.7%) | 5 (1.2%) | 0.62 (0.15–2.63) | 0.51 | AA | 19 (4.6%) | 17 (4%) | 1.16 (0.60–2.27) | 0.65 | | Overdominant | CC/GG | 371 (90%) | 356 (83.2%) | 1.00 | | CC/AA | 271 (65.8%) | 314 (73.4%) | 1.00 | | | CG | 41 (9.9%) | 72 (16.8%) | 0.55 (0.36–0.83) | 0.0033 | CA | 141 (34.2%) | 114 (26.6%) | 1.43 (1.06–1.92) | 0.017 | | Allele | | | | | Allele | | | | | | C | 775 (94%) | 774 (90%) | 1.00 | | C | 645 (78%) | 708 (83%) | 1.00 | | | G | 47 (6%) | 82 (10%) | 0.58 (0.40–0.84) | 0.0033 | A | 179 (22%) | 148 (17%) | 1.32 (1.04–1.67) | 0.024 |
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corresponds to the number of individuals; . |
