Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population

Table 3

Association between SNPs, rs7977932, and rs4758680 and clinic features of the epithelial ovarian cancer.

Clinical features	rs7977932				Clinical features	rs4758680
	Genotype frequency (%)		OR (95% CI)	P value		Genotype frequency (%)		OR (95% CI)	P value
FIGO stage	I-II	III-IV				I-II	III-IV
CC	76 (83.52%)	292 (90.97%)	1.00		CC	55 (60.44%)	197 (61.37%)	1.00
CG/GG	15 (16.48%)	29 (9.03%)	0.50 (0.26–0.99)	0.042	CA/AA	36 (39.56%)	124 (38.63%)	0.96 (0.60–1.55)	0.872
C	165 (90.66%)	612 (95.33%)	1.00		C	141 (77.47%)	504 (78.50%)	1.00
G	17 (9.34%)	30 (4.67%)	0.48 (0.26–0.88)	0.017	A	41 (22.53%)	138 (21.50%)	0.94 (0.63–1.40)	0.766
Tumor grade	G1-G2	G3				G1-G2	G3
CC	28 (87.50%)	340 (89.47%)	1.00		CC	21 (65.63%)	231 (60.79%)	1.00
CG/GG	4 (12.50%)	40 (10.53%)	0.82 (0.28–2.47)	0.961	CA/AA	11 (34.38%)	149 (39.21%)	1.23 (0.58–2.63)	0.590
C	60 (93.75%)	717 (94.34%)	1.00		C	53 (82.81%)	592 (77.89%)	1.00
G	4 (6.25%)	43 (5.66%)	0.90 (0.31–2.50)	0.779	A	11 (17.19%)	168 (22.11%)	1.37 (0.70–2.68)	0.360
Histological type	Serous	Others				Serous	Others
CC	295 (88.59%)	73 (92.41%)	1.00		CC	202 (60.66%)	50 (63.29%)	1.00
CG/GG	38 (11.41%)	6 (7.59%)	0.64 (0.26–1.57)	0.323	CA/AA	131 (39.34%)	29 (36.71%)	0.89 (0.54–1.49)	0.666
C	625 (93.84%)	152 (96.20%)	1.00		C	520 (78.08%)	125 (79.11%)	1.00
G	41 (6.16%)	6 (3.80%)	0.60 (0.25–1.44)	0.250	A	146 (21.92%)	33 (20.89%)	0.94 (0.62–1.44)	0.777
Age (years)	<50	≥50				<50	≥50
CC	164 (87.70%)	204 (90.67%)	1		CC	112 (59.89%)	140 (62.22%)	1
CG/GG	23 (12.30%)	21 (9.33%)	0.73 (0.40–1.37)	0.332	CA/AA	75 (40.11%)	85 (37.78%)	0.91 (0.61–1.35)	0.629
C	349 (93.32%)	428 (95.11%)	1.00		C	288 (77.01%)	357 (79.33%)	1.00
G	25 (6.68%)	22 (4.89%)	0.72 (0.40–1.30)	0.269	A	86 (22.99%)	93 (20.67%)	0.87 (0.63–1.22)	0.420

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