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Disease Markers
Volume 2018, Article ID 3729402, 7 pages
https://doi.org/10.1155/2018/3729402
Research Article

Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children

1Department of Endocrinology, Metabolism and Genetic Disorders, Children’s Hospital of Soochow University, Suzhou, Jiangsu, China
2Department of Cardiology, Children’s Hospital of Soochow University, Suzhou, Jiangsu, China
3Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Soochow University, Jiangsu, China

Correspondence should be addressed to Miao Hou; moc.621@123oaimuoh

Received 21 February 2018; Revised 5 June 2018; Accepted 25 June 2018; Published 29 July 2018

Academic Editor: Francesc Villarroya

Copyright © 2018 Fengyun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Progranulin (PGRN), a novel peptide that has recently emerged as an important regulatory adipokine, is relevant to energy homeostasis and obesity in animals and adult humans. Little is known about its roles in children. The aim of the current study was to determine the potential role of PGRN and explore its relationship to various obesity-related markers in obese children. This was a cross-sectional study composed of 77 children (43 obese and 34 healthy, age 8.68 ± 0.28 and 8.46 ± 0.45 years, resp.). The PGRN levels were significantly higher in obese children (102.44 ± 4.18 ng/mL) comparing to controls (69.32 ± 5.49 ng/mL) (). Moreover, the PGRN levels were positively correlated with triglyceride (TG), total cholesterol (TC), IL-6, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in obese children after adjusted for BMI and age. However, there was no correlation of serum PGRN levels with OGTT-derived dynamic parameters, HOMA-IR, or HOMA-β in obese children. The results suggest that serum PGRN levels are significantly higher in obese children in China and correlate significantly with obesity-related markers. Increased PGRN levels may be involved in the pathological mechanism of childhood obesity.