Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children
Table 1
The clinical and laboratory characteristics of obese and nonobese groups.
Variable
Obese subject
Nonobese subject
value
Age(years)
8.68 ± 0.28
8.46 ± 0.45
N.S
Boys/girls
13/30
22/12
N.S
BMI (kg/m2)
25.85 ± 0.38
15.40 ± 0.20
<0.01
SBP (mmHg)
111.63 ± 1.84
97.15 ± 0.81
<0.01
DBP (mmHg)
71.14 ± 1.48
65.76 ± 1.45
<0.01
Glucose (mmol/L)
4.39 ± 0.09
4.56 ± 0.13
N.S
HbAC1 (%)
4.47 ± 0.07
4.32 ± 0.05
<0.01
Insulin (μU/mL)
14.80 ± 1.28
4.31 ± 0.40
<0.01
HOMA-IR
2.86 ± 0.25
0.88 ± 0.09
<0.01
HOMA-β
402.02 ± 53.61
83.12 ± 8.48
<0.01
Insulinogenic index, ΔI30/ΔG30 (μU/mL per mmol/L)
42.15 ± 4.56
62.13 ± 4.12
<0.01
C-peptide index, ΔC30/ΔG30 (ng/mL per mmol/L)
2.99 ± 1.09
4.05 ± 0.76
<0.01
TG (mmol/L)
1.57 ± 0.15
0.86 ± 0.08
<0.01
TC (mmol/L)
4.17 ± 0.10
4.12 ± 0.13
N.S
LDL (mmol/L)
2.94 ± 0.10
2.70 ± 0.18
<0.05
HDL (mmol/L)
1.3 ± 0.03
1.56 ± 0.05
<0.01
GPT (U/L)
33.37 ± 5.18
17.17 ± 1.62
<0.01
GOT (U/L)
29.88 ± 2.11
26.89 ± 1.47
N.S
IL-6 (pg/mL)
8.79 ± 0.21
7.38 ± 0.18
<0.01
TNF-α (ng/L)
15.52 ± 0.56
11.34 ± 1.02
<0.05
hsCRP (mg/dl)
1.89 ± 0.30
0.38 ± 0.08
<0.01
Data are presented as means ± S.E.M. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HOMA-IR: homeostasis model assessment of insulin resistance; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TC: total cholesterol; TG: triglycerides.
