Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children
Table 2
The clinical and laboratory characteristics of insulin resistant and nonresistant obese subjects.
Variable
IR ()
Non-IR ()
value
Age (years)
8.79 ± 0.45
8.57 ± 0.34
N.S
Boys/girls
11/6
19/7
N.S
BMI (kg/m2)
25.70 ± 0.05
25.94 ± 0.05
N.S
SBP (mmHg)
111.65 ± 3.10
103.73 ± 4.48
N.S
DBP (mmHg)
74.47 ± 2.48
68.96 ± 1.75
N.S
Glucose (mmol/L)
4.39 ± 0.15
4.38 ± 0.12
N.S
HbAC1 (%)
4.59 ± 0.09
4.35 ± 0.09
N.S
Insulin (μU/mL)
23.14 ± 1.48
9.35 ± 0.80
<0.01
HOMA-IR
4.48 ± 0.28
1.79 ± 0.14
<0.01
HOMA-β
470.15 ± 70.15
367.95 ± 67.95
<0.01
Insulinogenic index, ΔI30/ΔG30 (μU/mL per mmol/L)
51.74 ± 7.62
34.74 ± 5.15
<0.05
C-peptide index, ΔC30/ΔG30 (ng/mL per mmol/L)
2.36 ± 0.27
3.39 ± 1.81
N.S
TG (mmol/L)
1.71 ± 0.27
1.59 ± 0.17
N.S
TC (mmol/L)
4.09 ± 0.18
4.22 ± 0.11
N.S
LDL (mmol/L)
2.82 ± 0.18
3.01 ± 0.11
N.S
HDL (mmol/L)
1.31 ± 0.06
1.30 ± 0.04
N.S
GPT (U/L)
42.89 ± 10.48
27.14 ± 4.98
N.S
GOT (U/L)
34.90 ± 4.36
26.59 ± 1.81
N.S
IL-6 (pg/mL)
8.32 ± 0.18
8.78 ± 0.22
N.S
TNF-α (ng/L)
62.82 ± 1.11
60.67 ± 0.05
N.S
hsCRP (mg/dl)
1.82 ± 0.27
1.93 ± 0.48
N.S
Data are presented as means ± S.E.M. IR: insulin resistant; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HOMA-IR: homeostasis model assessment of insulin resistance; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TC: total cholesterol; TG: triglycerides.
