Amino Acid-Based Metabolic Panel Provides Robust Prognostic Value Additive to B-Natriuretic Peptide and Traditional Risk Factors in Heart Failure
Prognostic value by combining B-natriuretic peptide (BNP) and HOP. Kaplan-Meier curves of HOP and BNP in the initiation (a and b) and the validation cohorts (d and e); the Kaplan-Meier curves of 4 subgroups in the initiation (c) and the validation cohorts (f), including high BNP and HOP (HBHH), high BNP and low HOP (HBLH), low BNP and high HOP (LBHH), and low BNP and low HOP (LBLH). High and low BNP are defined by and <750 pg/mL, respectively. High and low HOP are defined by and <14, respectively. HOP: a metabolic panel composed of histidine, ornithine, and phenylalanine.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.