Disease Markers / 2018 / Article / Tab 4

Research Article

Amino Acid-Based Metabolic Panel Provides Robust Prognostic Value Additive to B-Natriuretic Peptide and Traditional Risk Factors in Heart Failure

Table 4

Cox univariate and multivariable analysis for HF-related rehospitalization and death (initiation cohort).

ItemHazard ratio (95% CI) valueHazard ratio (95% CI) value

HOP score1.072 (1.044~1.100)<0.0011.057 (1.024~1.091)0.001
Log (BNP) × 10−11.078 (1.045~1.112)<0.0011.028 (0.995~1.063)0.102
Age (years)1.033 (1.020~1.046)<0.0011.029 (1.015~1.043)<0.001
Sex0.651 (0.478~0.886)0.0060.747 (0.519~1.075)0.116
LVEF (%)0.990 (0.980 ~1.000)0.050.989 (0.977~1.001)0.072
NYHA functional class ≥III4.196 (1.720~10.233)0.0021.455 (0.565~3.748)0.437
Stage D1.839 (1.416~2.388)<0.0011.417 (1.021~1.088)0.024
Systolic blood pressure (mmHg)0.996 (0.988~1.005)0.402
Diabetes mellitus1.685 (1.241~2.288)0.0011.360 (0.972~1.902)0.073
Chronic kidney disease2.058 (1.503~2.818)<0.0011.516 (1.078~2.132)0.017
Hypertension1.458 (1.035~2.054)0.0311.039 (0.712~1.516)0.843
Atrial fibrillation1.274 (0.926~1.751)0.136
Body mass index (kg/m2)0.971 (0.935~1.008)0.119
Serum sodium (mEq/L)0.976 (0.936~1.018)0.189
Hemoglobin (g/dL)0.873 (0.814~0.935)<0.0010.970 (0.887~1.059)0.495
Albumin (g/dL)0.531 (0.409~0.690)<0.0010.755 (0.546~1.044)0.089

BNP: B-type natriuretic peptide; chronic kidney disease, estimated glomerular filtration rate ; HOP: histidine, ornithine and phenylalanine; LVEF: left ventricular ejection fraction; NYHA: New York Heart Association.

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