CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer

Figure 1

Characteristics and analysis of the EGFR family expressions in thyroid cancer cells: (a) determination of EGFR member expressions using CCLE microarray gene database of all 1036 cancer cells. The expressions are divided into thyroid cancer cells (12 cells) and other cancer cell types (1024 cancer cells). (b) Determination of EGFR expression using TCGA clinical tumor microarray gene database of all 8215 tumors. The gene expressions are divided into thyroid tumors (513 tumors) and other tumor types (7702 tumors). The gene expressions were determined by fluorescence intensity. The statistical significance is given between groups by Student’s t-test. Immunocytochemistry of EGFR protein expressions (brown stain) in (c) human papillary, (d) follicular, (e) anaplastic thyroid cancers, and (f) normal thyroid gland tissues was obtained from the Human Protein Atlas and presented in low- (left photo) and high-power fields (right photo). Scale bar = 50 μM.

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