Disease Markers / 2018 / Article / Tab 1

Research Article

A Noninvasive Score to Predict Liver Fibrosis in HBeAg-Positive Hepatitis B Patients with Normal or Minimally Elevated Alanine Aminotransferase Levels

Table 1

Characteristics of patients in the training and validation groups.

Training groupValidation group

20387 
Age (years)31 (26, 41)34 (29, 40)0.067
Gender (male/female)121/8250/370.735
BMI (kg/m2)0.447
Family member of HBV infection (yes/no)143/6061/260.955
Smoking (yes/no)41/16224/630.167
Drinking (yes/no)26/1779/780.555
Lg HBV DNA (IU/ml)7.544 (6.839, 7.968)8.358 (6.340, 8.727)<0.001
Lg HBsAg (IU/ml)4.411 (3.811, 4.751)4.424 (3.636, 4.834)0.575
Lg HBeAg (S/CO)3.098 (2.442, 3.162)3.139 (2.217, 3.195)0.103
Anti-HBc (S/CO)9.800 (8.300, 11.000)8.840 (7.440, 9.520)<0.001
WBC (×109/l)5.700 (4.700, 6.510)5.830 (4.920, 7.030)0.219
RBC (×1012/l)<0.001
Platelet (×109/l)0.579
AFP (ng/ml)5.200 (3.400, 9.200)2.670 (1.780, 4.140)<0.001
ALT (IU/l)32.000 (25.000, 46.000)32.000 (21.000, 51.000)0.661
AST (IU/l)26.000 (20.000, 33.000)28.000 (21.000, 35.000)0.146
Tbil (μmol/l)11.000 (8.000, 15.000)11.100 (7.900, 13.700)0.526
Dbil (μmol/l)4.000 (3.000, 5.500)4.400 (3.300, 5.800)0.112
Albumin (g/l)0.021
Globulin (g/l)0.967
GGT (IU/l)18.000 (12.000, 30.000)18.000 (11.000, 25.000)0.674
INR<0.001
HA (ng/ml)42.930 (17.000, 71.000)50.290 (37.950, 62.220)0.090
Laminin (ng/ml)29.000 (8.000, 63.000)50.040 (29.460, 72.130)<0.001
IV-C (ng/ml)34.000 (15.100, 58.000)43.220 (23.420, 67.280)0.014
PC-III (ng/ml)2.000 (0.200, 4.000)4.410 (3.320, 6.100)<0.001
LSM (kPa)5.400 (4.700, 6.500)4.900 (4.200, 6.600)0.063
Portal vein width (cm)1.100 (1.110, 1.200)1.200 (1.100, 1.200)0.001
Spleen thickness (cm)0.330
Liver fibrosis staging (F0–1/F2–4)164/3954/330.001

BMI: body mass index; WBC: white blood cell; RBC: red blood cell; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Tbil: total bilirubin; Dbil: direct bilirubin; GGT: gamma-glutamyltranspeptidase; INR: international normalized ratio; HA: hyaluronic acid; IV-C: type IV collagen; PC-III: type III procollagen; LSM: liver stiffness measurement.

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