A Noninvasive Score to Predict Liver Fibrosis in HBeAg-Positive Hepatitis B Patients with Normal or Minimally Elevated Alanine Aminotransferase Levels
Table 1
Characteristics of patients in the training and validation groups.
Training group
Validation group
203
87
Age (years)
31 (26, 41)
34 (29, 40)
0.067
Gender (male/female)
121/82
50/37
0.735
BMI (kg/m2)
0.447
Family member of HBV infection (yes/no)
143/60
61/26
0.955
Smoking (yes/no)
41/162
24/63
0.167
Drinking (yes/no)
26/177
9/78
0.555
Lg HBV DNA (IU/ml)
7.544 (6.839, 7.968)
8.358 (6.340, 8.727)
<0.001
Lg HBsAg (IU/ml)
4.411 (3.811, 4.751)
4.424 (3.636, 4.834)
0.575
Lg HBeAg (S/CO)
3.098 (2.442, 3.162)
3.139 (2.217, 3.195)
0.103
Anti-HBc (S/CO)
9.800 (8.300, 11.000)
8.840 (7.440, 9.520)
<0.001
WBC (×109/l)
5.700 (4.700, 6.510)
5.830 (4.920, 7.030)
0.219
RBC (×1012/l)
<0.001
Platelet (×109/l)
0.579
AFP (ng/ml)
5.200 (3.400, 9.200)
2.670 (1.780, 4.140)
<0.001
ALT (IU/l)
32.000 (25.000, 46.000)
32.000 (21.000, 51.000)
0.661
AST (IU/l)
26.000 (20.000, 33.000)
28.000 (21.000, 35.000)
0.146
Tbil (μmol/l)
11.000 (8.000, 15.000)
11.100 (7.900, 13.700)
0.526
Dbil (μmol/l)
4.000 (3.000, 5.500)
4.400 (3.300, 5.800)
0.112
Albumin (g/l)
0.021
Globulin (g/l)
0.967
GGT (IU/l)
18.000 (12.000, 30.000)
18.000 (11.000, 25.000)
0.674
INR
<0.001
HA (ng/ml)
42.930 (17.000, 71.000)
50.290 (37.950, 62.220)
0.090
Laminin (ng/ml)
29.000 (8.000, 63.000)
50.040 (29.460, 72.130)
<0.001
IV-C (ng/ml)
34.000 (15.100, 58.000)
43.220 (23.420, 67.280)
0.014
PC-III (ng/ml)
2.000 (0.200, 4.000)
4.410 (3.320, 6.100)
<0.001
LSM (kPa)
5.400 (4.700, 6.500)
4.900 (4.200, 6.600)
0.063
Portal vein width (cm)
1.100 (1.110, 1.200)
1.200 (1.100, 1.200)
0.001
Spleen thickness (cm)
0.330
Liver fibrosis staging (F0–1/F2–4)
164/39
54/33
0.001
BMI: body mass index; WBC: white blood cell; RBC: red blood cell; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Tbil: total bilirubin; Dbil: direct bilirubin; GGT: gamma-glutamyltranspeptidase; INR: international normalized ratio; HA: hyaluronic acid; IV-C: type IV collagen; PC-III: type III procollagen; LSM: liver stiffness measurement.
