The Abnormal Expression of MicroRNA-542-3p in Hepatocellular Carcinoma and Its Clinical Significance

Figure 2

Relative expression level of miRNA-542-3p in HCC tissue and adjacent normal liver tissue and its relationship with clinicopathological parameters. (a) miRNA-542-3p expression level was significantly downregulated in the 72 paired HCC tissues compared with the adjacent normal liver tissues. (b) Highly aggressive tumors tend to have lower miRNA-542-3p expression. Differentiation: A—low/moderate differentiation; B—high differentiation. Portal invasion: A—positive; B—negative. Tumor size: A—≥10 cm; B—<10 cm. (c, d, e) ROC curve analysis of miR-542-3p expression levels for judging aggressive clinicopathologic characteristics. Differentiation: AUC = 0.672 (61.9% sensitivity, 78.4% specificity). Portal invasion: AUC = 0.728 (55.6% sensitivity, 88.9% specificity). Tumor size: AUC = 0.700 (58.6% sensitivity, 79.1% specificity). Results are expressed as mean ± SD. All data were analyzed using Student’s t-test. , .

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