Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas

Figure 1

Schematic representation of HuR regulation and function. HuR modulators (proteins, microRNAs, hormones, drugs, and cellular environmental conditions) may affect HuR expression, activity, and subcellular localisation. HuR nucleocytoplasmic shuttling is controlled via posttranslational modifications (e.g., phosphorylation). HuR binds to mRNAs through its 3 RNA recognition motifs (RRMs); it has been implicated in splicing and polyadenylation and most importantly in positive regulation of mRNA stability and positive or negative regulation of transcription.