Application of Lactoferrin and α1-Antitrypsin in Gingival Retention Fluid to Diagnosis of Periodontal Disease

Table 4

ROC curve analysis of lactoferrin in GRF or saliva.

Outcomes	AUC (95% CI)	value	Cutoff (ng/mL)	Sensitivity	Specificity	PLR	NLR
For ≥30% of PD ≥ 4 mm
Lactoferrin in GRF	0.76 (0.60–0.92)	<0.01	68.6	0.81	0.72	2.9	0.3
Lactoferrin in saliva	0.67 (0.50–0.84)	0.04	7585.8	0.50	0.83	2.9	0.3
For ≥20% of BOP
Lactoferrin in GRF	0.60 (0.46–0.75)	0.16	61.2	0.55	0.56	1.3	0.8
Lactoferrin in saliva	0.70 (0.57–0.83)	<0.01	3715.4	0.61	0.72	3.6	0.5

ROC: receiver operating characteristic, PD: probing pocket depth, BOP: bleeding on probing, GRF: gingival retention fluid, AUC: area under the curve, CI: confidence interval, PLR: positive likelihood ratio, NLR: negative likelihood ratio. Significance level: , .