Application of Lactoferrin and α1-Antitrypsin in Gingival Retention Fluid to Diagnosis of Periodontal Disease

Table 5

ROC curve analysis of α1-antitrypsin in GRF or in saliva.

Outcomes	AUC (95% CI)	value	Cutoff (ng/mL)	Sensitivity	Specificity	PLR	NLR
For ≥30% of PD ≥ 4 mm
α1-antitrypsin in GRF	0.76 (0.62–0.90)	<0.01	54.5	0.81	0.60	2.0	0.5
α1-antitrypsin in saliva	0.77 (0.65–0.90)	<0.01	8871.6	0.69	0.83	4.0	0.2
For ≥20% of BOP
α1-antitrypsin in GRF	0.76 (0.64–0.88)	<0.01	35.3	0.84	0.53	1.8	0.6
α1-antitrypsin in saliva	0.81 (0.70–0.92)	<0.01	4265.8	0.74	0.63	2.0	0.5

ROC: receiver operating characteristic, PD: probing pocket depth, BOP: bleeding on probing, GRF: gingival retention fluid, AUC: area under the curve, CI: confidence interval, PLR: positive likelihood ratio, NLR: negative likelihood ratio. Significance level: , .