Clinical Value of Combined Determination of Serum B7-H4 with Carcinoembryonic Antigen, Osteopontin, or Tissue Polypeptide-Specific Antigen for the Diagnosis of Colorectal Cancer

Table 3

The association between serum B7-H4, OPN, TPS, and CEA levels and CRC clinicopathological parameters.

Patient characteristics		B7-H4 (ng/mL)		OPN (ng/mL)		TPS (U/L)		CEA (ng/mL)
		Age
<60	32	97.64 ± 15.64	0.249	130.06 ± 65.98	0.516	96.25 ± 17.59	0.452	70.58 ± 21.50	0.764
≥ 60	27	93.57 ± 10.06		111.60 ± 47.57		101.74 ± 36.28		85.03 ± 13.54
Gender
Male	41	94.38 ± 12.24	0.303	139.78 ± 63.91	0.373	100.01 ± 33.14	0.723	97.14 ± 23.01	0.279
Female	18	98.13 ± 15.23		113.68 ± 48.70		96.66 ± 14.75		76.51 ± 43.64
Tumor masses
<5 cm	32	89.19 ± 12.56	0.016	110.87 ± 41.61	0.567	91.23 ± 10.39	0.027	63.24 ± 39.87	0.253
≥5 cm	27	102.68 ± 45.29		113.82 ± 57.77		109.19 ± 30.17		92.71 ± 53.42
Infiltration
Inside serosal layer	35	86.75 ± 11.31	0.0001	100.47 ± 42.68	0.040	98.53 ± 11.39	0.962	56.94 ± 59.83	0.365
Reached and outside serosal layer	24	100.41 ± 12.10		145.21 ± 60.06		98.89 ± 33.16		92.61 ± 34.21
Metastasized
Nonmetastasized	48	83.34 ± 25.23	0.0041	121.50 ± 28.26	0.015	94.47 ± 29.98	0.021	61.00 ± 33.23	0.069
Metastasized	11	116.34 ± 40.82		110.68 ± 57.50		123.01 ± 44.55		95.00 ± 39.82
Lymph node metastasis
<4	17	91.945 ± 19.43	0.0052	108.57 ± 50.32	0.353	98.50 ± 29.17	0.443	74.96 ± 26.85	0.106
≥4	42	110.70 ± 16.52		136.99 ± 63.07		105.15 ± 10.50		81.57 ± 19.16
Differentiation
Low	7	91.72 ± 9.62	0.135	113.47 ± 44.02	0.203	98.30 ± 16.91	0.573	90.24 ± 17.66	0.109
Middle	47	101.46 ± 11.48		120.43 ± 29.01		104.52 ± 27.24		82.47 ± 23.09
High	5	100.42 ± 17.34		121.06 ± 31.33		102.84 ± 15.22		85.24 ± 32.6
Histology
Squamous	2	98.72 ± 11.56	0.283	122.47 ± 35.16	0.121	103.88 ± 12.46	0.332	85.58 ± 31.50	0.238
Mucoid	57	96.28 ± 15.34		117.29 ± 40.91		95.45 ± 39.67		75.42 ± 33.54