Clinical Value of Combined Determination of Serum B7-H4 with Carcinoembryonic Antigen, Osteopontin, or Tissue Polypeptide-Specific Antigen for the Diagnosis of Colorectal Cancer

Table 4

The diagnosis value of serum B7-H4/OPN/TPS/CEA in CRC patients.

Test variable	Sensitivity (%)	Specificity (%)	Youden index
B7-H4	88.2	66.2	0.544
OPN	79.8	61.7	0.415
TPS	76.3	67.5	0.438
CEA	59.3	83.3	0.426
Combinational (B7-H4 + OPN)	99.2	55.9	0.511
Combinational (B7-H4 + TPS)	99.0	60.1	0.591
Combinational (B7-H4 + CEA)	98.9	80.4	0.793