TGF-β Polymorphisms Are a Risk Factor for Chagas Disease

Table 5

Genotype and allele distribution of TGFB1 –800 G/A, −509 C/T, +10 T/C, +25 G/C, and +263 C/T polymorphisms among patients with indeterminate and cardiac forms of Chagas disease.

	IND; (%)	A + B; (%)	C + D; (%)	x^2 ()
	−800 G/A
Genotype
GG	45 (84.91)	46 (86.79)	43 (81.13)	2.15 (0.71)
AG	8 (15.09)	3 (5.66)	6 (11.32)
AA	0 (0)	0 (0)	1 (1.89)
Allele
G	98 (92.45)	95 (96.94)	92 (92.00)	2.53 (0.28)
A	8 (7.55)	3 (3.06)	8 (8)
	−509 C/T
Genotype
CC	3 (5.66)	4 (7.55)	3 (5.66)	0.58 (0.96)
CT	23 (43.40)	24 (45.28)	21 (39.62)
TT	27 (50.94)	21 (39.62)	26 (49.06)
Allele
C	29 (27.36)	32 (32.65)	27 (27.00)	0.97 (0.61)
T	77 (72.64)	66 (67.35)	73 (73.00)
	+10 T/C
Genotype
TT	3 (5.66)	8 (15.09)	3 (5.66)	4.08 (0.39)
TC	31 (58.49)	31 (58.49)	31 (58.49)
CC	19 (35.85)	10 (18.87)	16 (30.19)
Allele
T	37 (34.91)	47 (47.96)	37 (37.00)	4.11 (0.13)
C	69 (65.09)	51 (52.04)	63 (63.00)
	+25 G/C
Genotype
GG	47 (88.68)	43 (81.13)	41 (77.36)	1.63 (0.80)
GC	5 (9.43)	6 (11.32)	9 (16.98)
CC	1 (1.89)	0 (0)	0 (0)
Allele
G	99 (93.40)	92 (93.88)	91 (91.00)	0.71 (0.70)
C	7 (6.60)	6 (6.12)	9 (9.00)
	+263 C/T
Genotype
CC	51 (96.23)	47 (88.68)	48 (90.57)	0.01 (0.99)
CT	2 (3.77)	2 (3.77)	2 (3.77)
TT	0 (0)	0 (0)	0 (0)
Allele
C	104 (98.11)	96 (97.96)	98 (98.00)	0.01 (0.99)
T	2 (1.89)	2 (2.04)	2 (2.00)