SP110 Polymorphisms Are Genetic Markers for Vulnerability to Latent and Active Tuberculosis Infection in Taiwan
Table 4
Association analyses of SP110 SNP genotypes with LTBI and TB susceptibility in various inheritance models.
(a) Association analyses of SP110 SNP genotypes in an additive model
SNP ID
TB vs. health
TB vs. LTBI
LTBI vs. health
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
rs9061
0.89 (0.66,1.2)
0.4382
2.17 (1.16,4.06)
0.015
0.41 (0.22,0.78)
0.0059
rs7580900
1.07 (0.83,1.38)
0.5839
0.64 (0.43,0.95)
0.0261
1.62 (1.1,2.39)
0.0147
rs3820974
0.94 (0.72,1.23)
0.6661
1.2 (0.79,1.82)
0.4009
0.79 (0.51,1.21)
0.2761
rs41309108
0.9 (0.66,1.22)
0.4917
1.2 (0.73,1.97)
0.4824
0.73 (0.44,1.23)
0.2366
rs7580912
1.05 (0.8,1.37)
0.7307
0.74 (0.49,1.1)
0.1387
1.4 (0.94,2.08)
0.0992
rs1135791
1.2 (0.83,1.73)
0.3242
1.46 (0.77,2.77)
0.2444
0.81 (0.42,1.56)
0.525
rs1365776
1.1 (0.75,1.62)
0.6153
1.32 (0.7,2.5)
0.3933
0.84 (0.43,1.65)
0.6133
rs10498244
1.1 (0.77,1.59)
0.5919
1.4 (0.71,2.73)
0.3303
0.77 (0.4,1.5)
0.4457
rs2241525
0.91 (0.66,1.25)
0.5681
0.62 (0.4,0.98)
0.0407
1.46 (0.92,2.32)
0.1102
rs11556887
0.72 (0.48,1.08)
0.1155
0.75 (0.41,1.39)
0.362
0.96 (0.5,1.81)
0.8916
OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.
(b) Association analyses of SP110 SNP genotypes in a dominant model
SNP ID
TB vs. health
TB vs. LTBI
LTBI vs. health
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
rs9061
0.87 (0.6,1.26)
0.4646
2.14 (1.09,4.22)
0.0273
0.42 (0.21,0.82)
0.0112
rs7580900
1.22 (0.84,1.76)
0.2929
0.68 (0.37,1.27)
0.2276
1.74 (0.93,3.24)
0.083
rs3820974
0.93 (0.65,1.32)
0.6879
1.3 (0.76,2.24)
0.3378
0.71 (0.41,1.23)
0.2193
rs41309108
0.86 (0.6,1.23)
0.4092
1.15 (0.66,2.01)
0.6191
0.74 (0.42,1.3)
0.2917
rs7580912
1.18 (0.83,1.68)
0.3571
0.98 (0.55,1.72)
0.9312
1.2 (0.68,2.12)
0.5388
rs1135791
1.2 (0.81,1.78)
0.3678
1.41 (0.72,2.75)
0.3146
0.83 (0.42,1.64)
0.5948
rs1365776
1.03 (0.66,1.6)
0.9033
1.34 (0.64,2.82)
0.4408
0.79 (0.37,1.67)
0.5353
rs10498244
1.15 (0.77,1.72)
0.4807
1.75 (0.81,3.78)
0.1536
0.63 (0.29,1.35)
0.2341
rs2241525
0.87 (0.59,1.27)
0.4667
0.55 (0.31,0.97)
0.0389
1.57 (0.88,2.78)
0.1239
rs11556887
0.66 (0.43,1.02)
0.0609
0.67 (0.35,1.3)
0.2363
0.97 (0.51,1.86)
0.9282
OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.
(c) Association analyses of SP110 SNP genotypes in a recessive model
SNP ID
TB vs. health
TB vs. LTBI
LTBI vs. health
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
rs9061
0.82 (0.38,1.78)
0.6227
—
—
—
—
rs7580900
0.92 (0.57,1.48)
0.737
0.45 (0.24,0.84)
0.0117
2.13 (1.13,4.03)
0.0195
rs3820974
0.92 (0.52,1.62)
0.7796
1.13 (0.45,2.83)
0.8018
0.84 (0.33,2.15)
0.7209
rs41309108
1.05 (0.41,2.66)
0.9241
2.35 (0.3,18.52)
0.4186
0.43 (0.05,3.55)
0.437
rs7580912
0.79 (0.44,1.42)
0.4367
0.35 (0.17,0.72)
0.0043
2.49 (1.2,5.18)
0.0142
rs1135791
1.63 (0.36,7.51)
0.5284
—
—
—
—
rs1365776
2.25 (0.63,8.05)
0.2129
1.94 (0.23,16.11)
0.5375
1.24 (0.13,11.51)
0.8504
rs10498244
0.74 (0.18,3.05)
0.6804
0.38 (0.06,2.23)
0.2844
2.27 (0.42,12.19)
0.3385
rs2241525
1.05 (0.42,2.6)
0.9172
0.56 (0.17,1.83)
0.3374
1.73 (0.52,5.81)
0.3747
rs11556887
2.63 (0.27,25.7)
0.4064
—
—
—
—
OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic. ORs remain significant after false discovery rate (FDR) correction.
