SP110 Polymorphisms Are Genetic Markers for Vulnerability to Latent and Active Tuberculosis Infection in Taiwan

Table 5

Association of the haplotype frequencies of SP110 SNPs with 3 SNPs (rs9061, rs7580900, and rs7580912) with LTBI and TB susceptibility.

(a) Association of haplotype frequencies with LTBI risk in LTBI cases and healthy controls

Haplotypes	Frequencies		Chi-square	OR (95% CI)	value
	LTBI	Health
GAA	0.417	0.558	8.417	1.77 (1.20-2.60)	0.0037
GGG	0.310	0.179	11.048	2.06 (1.34-3.17)	9.00E − 04
AGG	0.053	0.120	4.997	0.41 (0.18-0.92)	0.0254
GGA	0.134	0.052	10.99	2.81 (1.49-5.27)	9.00E − 04
AGA	0.021	0.043	1.429	0.47 (0.13-1.68)	0.232
AAA	0.019	0.042	1.579	0.44 (0.12-1.65)	0.209
GAG	0.047	0.005	14.5	10.00 (2.36-42.32)	1.00E − 04

OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.

(b) Association of haplotype frequencies with TB risk in TB cases vs. LTBI individuals

Haplotypes	Frequencies		Chi-square	OR (95% CI)	value
	TB	LTBI
GAA	0.540	0.417	6.445	0.61 (0.42-0.90)	0.0111
GGG	0.228	0.313	4.184	0.65 (0.43-0.98)	0.0408
AGG	0.103	0.053	3.191	2.05 (0.91-4.62)	0.074
GGA	0.043	0.130	14.591	0.30 (0.16-0.57)	0.0001
AGA	0.045	0.021	1.564	2.16 (0.62-7.49)	0.211
AAA	0.035	0.018	0.993	1.95 (0.51-7.53)	0.3191
GAG	0.005	0.047	16.031	0.10 (0.02-0.40)	0.0001

OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.