Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery
Table 2
MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio as diagnostic biomarkers of sepsis.
AUC-ROC (95% CI)
MMP-9
TIMP-1
MMP-9/TIMP-1 ratio
Nonoperated controls versus operated controls
0 h
0.798 (0.702–0.895)
0.584 (0.465–0.704)
0.761 (0.664–0.858)
Sepsis versus nonoperated controls
0 h
0.675 (0.561–0.789)
0.940 (0.889–0.991)
0.924 (0.873–0.975)
24 h
0.640 (0.511–0.769)
0.972 (0.941–1.004)
0.929 (0.878–0.980)
48 h
0.593 (0.450–0.736)
0.929 (0.862–0.997)
0.914 (0.853–0.975)
72 h
0.591 (0.417–0.765)
0.951 (0.892–1.006)
0.901 (0.821–0.980)
96 h
0.646 (0.457–0.826)
0.925 (0.825–1.026)
0.911 (0.825–0.997)
Sepsis versus operated controls
0 h
0.541 (0.418–0.664)
0.854 (0.778–0.930)
0.788 (0.697–0.879)
24 h
0.513 (0.372–0.653)
0.870 (0.797–0.943)
0.753 (0.650–0.855)
48 h
0.570 (0.415–0.724)
0.820 (0.728–0.913)
0.718 (0.605–0.832)
72 h
0.523 (0.342–0.703)
0.857 (0.768–0.913)
0.724 (0.593–0.854)
96 h
0.514 (0.307–0.721)
0.845 (0.738–0.952)
0.750 (0.612–0.888)
Data are presented as AUC-ROC (95% CI). . AUC-ROC: area under receiver operating characteristic curve; MMP-9: matrix metalloproteinase-9; TIMP-1: tissue inhibitor of matrix metalloproteinase-1.
