Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery

Table 3

Correlation analysis.

	MMP-9	TIMP-1	MMP-9/TIMP-1 ratio
Disease severity scores
APACHE II	−0.099	0.107	−0.116
SOFA	−0.149	0.181	−0.196
Biomarkers of inflammation
WBC	0.377	0.018	0.268
CRP	−0.047	0.019	−0.037
PCT	−0.246	0.150	−0.214
Biomarkers of kidney injury
Urea	−0.154	0.103	−0.167
Creatinine	−0.187	0.153	−0.234
Serum NGAL	−0.089	0.271	−0.203
Urine NGAL	−0.277	0.197	−0.338
KIM-1	0.002	0.144	−0.104
Biomarkers of liver injury
AST	−0.145	0.236	−0.210
ALT	−0.051	0.148	−0.097
Total bilirubin	−0.290	0.102	−0.266
Direct bilirubin	−0.299	0.143	−0.263
Biomarkers of coagulation
Platelets	0.371	−0.103	0.329
INR	−0.112	0.153	−0.127
aPTT	−0.143	0.102	0.135
Biomarkers of metabolic disorders
Total protein	0.113	−0.109	0.120
Glucose	−0.062	0.270	−0.246
Lactate	−0.211	0.263	−0.275

Kendall’s Tau-b correlation analysis. The correlation is significant at the 0.01 level (2-tailed); the correlation is significant at the 0.05 level (2-tailed). MMP-9: matrix metalloproteinase-9; TIMP-1: tissue inhibitor of matrix metalloproteinase-1; APACHE II: Acute Physiology and Chronic Health Evaluation II score; SOFA: Sequential Organ Failure Assessment score; WBC: white blood cell; CRP: C-reactive protein; PCT: procalcitonin; NGAL: neutrophil gelatinase-associated lipocalin; KIM-1: kidney injury molecule-1; AST: aspartate aminotransferase; ALT: alanine aminotransferase; INR: international normalized ratio; aPTT: activated partial thromboplastin time.