The Protein Expression of PDL1 Is Highly Correlated with Those of eIF2α and ATF4 in Lung Cancer
Table 2
Protein expressions of subjects with paired samples of both the tumor and normal tissues.
All
Adenocarcinoma
Squamous cell carcinoma
Normal tissue
Tumor tissue
Normal tissue
Tumor tissue
Normal tissue
Tumor tissue
STAT1
1.49 (0.68–3.46)
1.84 (0.55–21.8)
[0.06]
1.66 (0.8–3.02) {0.13}
1.95 (0.55–14.5) {0.53}
[0.502]
1.09 (0.63–3.46)
1.46 (0.83–5.77)
[0.69]
IRF1
2.23 (1.08–4.45)
2.32 (0.45–4.38)
[0.69]
2.25 (1.24–4.45) {0.21}
2.40 (0.56–4.38) {0.69}
[0.95]
1.69 (1.18–2.92)
1.69 (0.45–4.35)
[0.94]
PDL1
13.5 (5.87–32.9)
12.6 (2.27–36.4)
[0.26]
13.5 (9.85–32.9) {0.33}
13.5 (2.57–21.3) {0.91}
[0.30]
10.7 (7.11–29.9)
11.7 (2.27–36.4)
[0.94]
eIF2α
4.57 (0.55–7.67)
4.81 (1.21–14.7)
[0.40]
4.64 (2.17–6.51) {0.66}
4.99 (2.08–14.7) {0.53}
[0.39]
4.23 (2.67–7.67)
3.75 (1.21–8.11)
[1.00]
ATF4
2.43 (0.83–4.79)
2.10 (0.37–5.96)
[0.21]
2.50 (1.76–4.30) {0.13}
2.57 (0.56–3.16) {0.64}
[0.39]
1.79 (0.97–4.60)
1.63 (0.37–5.96)
[0.94]
INFAR1
0.12 (0.02–0.23)
0.13 (0.02–0.50)
[0.02]
0.12 (0.02–0.23) {0.61}
0.15 (0.02–0.50) {0.53}
[0.02]
0.09 (0.02–0.23)
0.15 (0.03–0.38)
[0.11]
IRF7
1.30 (0.65–2.26)
1.74 (0.17–12.8)
[0.003]
1.28 (0.90–2.56) {0.13}
1.43 (0.17–2.65) {0.001}
[0.58]
1.03 (0.66–1.94)
3.31 (1.65–12.83)
[0.03]
STAT2
6.70 (0.74–10.5)
8.54 (3.51–14.0)
[0.01]
7.36 (0.99–10.5) {0.001}
6.74 (3.51–14.0) {0.17}
[0.71]
3.75 (0.74–7.15)
9.74 (4.81–11.7)
[0.02]
Data presented as median with range in parenthesis are the ratio of the protein levels of molecules to those of β-actin in arbitrary units. Value in square brackets denotes the value of the difference between the normal and tumor tissues of a specific group. Value in curly brackets denotes the value of the difference between the same type of tissue of adenocarcinoma and squamous cell carcinoma.
