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Disease Markers
Volume 2018, Article ID 5214376, 7 pages
Research Article

Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy

1Department of Laboratory Medicine, Sanmen Hospital of Traditional Chinese Medicine, Taizhou, Zhejiang Province, China
2Department of Laboratory Medicine, Sanmen People’s Hospital, Taizhou, Zhejiang Province, China
3Center of Laboratory Medicine, Zhejiang Provincial People’s Hospital and People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang Province, China
4Department of Laboratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
5Department of Laboratory Medicine, Jiaxing Blood Center, Jiaxing, Zhejiang Province, China

Correspondence should be addressed to Xianming Fei; moc.361@ytinutrof

Received 22 August 2017; Revised 24 November 2017; Accepted 14 December 2017; Published 4 February 2018

Academic Editor: Michele Malaguarnera

Copyright © 2018 Lianlian Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It would be important to predict type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). This study was aimed at evaluating the predicting significance of hemostatic parameters for T2DM and DN. Plasma coagulation and hematologic parameters before treatment were measured in 297 T2DM patients. The risk factors and their predicting power were evaluated. T2DM patients without complications exhibited significantly different activated partial thromboplastin time (aPTT), platelet (PLT), and D-dimer (D-D) levels compared with controls (). Fibrinogen (FIB), PLT, and D-D increased in DN patients compared with those without complications (). Both aPTT and PLT were the independent risk factors for T2DM (OR: 1.320 and 1.211, , resp.), and FIB and PLT were the independent risk factors for DN (OR: 1.611 and 1.194, , resp.). The area under ROC curve (AUC) of aPTT and PLT was 0.592 and 0.647, respectively, with low sensitivity in predicting T2DM. AUC of FIB was 0.874 with high sensitivity (85%) and specificity (76%) for DN, and that of PLT was 0.564, with sensitivity (60%) and specificity (89%) based on the cutoff values of 3.15 g/L and 245 × 109/L, respectively. This study suggests that hemostatic parameters have a low predicting value for T2DM, whereas fibrinogen is a powerful predictor for DN.