Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy

Table 2

Comparisons of hemostatic parameters of T2DM patients with those of healthy controls.

Variables	Controls	Without complications	Diabetic nephropathy	value
n	141	202	95
Gender (M/F)	78/53	121/81	44/30	>0.05
Age (median) (years)	56 (33–79)	57 (31–82)	67 (35–87)	>0.05
PT (s)	11.02 ± 0.56	11.4 ± 2.12	12.2 ± 4.62	>0.05
INR	0.98 ± 0.05	1.02 ± 0.19	1.06 ± 0.45	>0.05
APTT (s)	27.5 ± 2.56	25.1 ± 3.7	24.7 ± 4.8	>0.05
FIB (g/L)	2.65 ± 0.40	2.75 ± 0.83	3.51 ± 1.33	<0.01
PLT (10^9/L)	211 (89–323)	183 (43–447)	207 (79–709)	<0.01
D-D (median) (mg/L)	0.14 (0.03–0.54)	0.18 (0.04–4.27)	0.48 (0.06–10.31)	<0.01
FDR (median) (g/mg)	18.94 ± 3.11	17.19 ± 4.12	7.31 ± 2.12	<0.01
TT (s)	17.6 ± 0.83	17.6 ± 0.95	17.5 ± 1.21	>0.05

Data were presented as mean and standard deviation (SD) or median (range). T2DM: type 2 diabetes mellitus; PT: prothrombin time; INR: international normalized ratio; aPTT: activated partial thromboplastin time; FIB: fibrinogen; PLT: platelet count; D-D: D-dimer; FDR: fibrinogen-D-dimer ratio; TT: thrombin time. value: comparisons of the three groups by one-way analysis of variance. compared with controls and patients with T2DM without complications; compared with controls.