The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

Figure 2

CES2 expression in human colorectal cancer and adjacent normal tissues was quantified by real-time reverse transcriptase PCR. (a) CES2 mRNA was significantly decreased in the tumor tissue. 18S rRNA was used as a reference gene. by paired two-tailed t-test. (b) The CES2 expression levels were compared between tumors with TP53 mutations generating nonfunctional p53 protein and tumors without TP53 mutations. . A Tukey-Kramer test was used. (c) The relationship between CES2 expression and the position of TP53 mutations. The plot indicates the codon distribution of the TP53 missense mutations (x-axis), and the samples’ corresponding CES2 expression levels (y-axis). The blue dots and the arrows indicate the samples with the R175H mutation. The orange dot indicates the sample with the R273H mutation.

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