Does the Risk of Ovarian Malignancy Algorithm Provide Better Diagnostic Performance Than HE4 and CA125 in the Presurgical Differentiation of Adnexal Tumors in Polish Women?

Table 2

Difference in serum tumor markers among groups by the Mann–Whitney U test.

Group studied	Tumor marker	Mean serum tumor marker levels among nonmalignant adnexal masses	Mean serum tumor marker levels among malignant adnexal masses	value
Whole group ()	HE4 (pmol/L)	53.3	1138.8	<0.001
	CA125 (U/mL)	41.8	588.3	<0.001
Premenopausal subgroup ()	HE4 (pmol/L)	46.6	673.6	<0.001
	CA125 (U/mL)	48.1	1138.8	0.008
Postmenopausal subgroup ()	HE4 (pmol/L)	69.3	1255.1	<0.001
	CA125 (U/mL)	26.5	450.7	<0.001