Is Total Serum Nitrite and Nitrate (NOx) Level in Dengue Patients a Potential Prognostic Marker of Dengue Hemorrhagic Fever?
Box 1
Clinical categorization of DHF according to the 2011 guidelines of WHO (SEARO) [5].
(i) Fever: acute onset of high fever which is lasting for two to seven days.
(ii) Thrombocytopenia (100,000 cells per mm3 or less)
(iii) Evidence for high vascular permeability (plasma leakage):
(a) Presence of pleural effusion and/or abdominal ascites using chest X-ray or ultrasound scanning. This is the most objective evidence of plasma leakage and particularly useful for diagnosis of DHF.
(b) Hypoproteinemia
(c) Haemoconcentration: rising hematocrit ≥ 20% from the baseline levels (baseline levels for male is around 40% and for female it is 36%)
(iv) Hemorrhagic manifestation most common as positive tourniquet test, petechiae, ecchymosis, epistaxis, gum bleeding, and haematemesis and/or melaena
