Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis

Table 3

lncRNAs and relevant targets in gastrointestinal cancer.

lncRNAs ()	Poor prognosis	Role	Relevant targets	Function	Reference
SNHG20^↑	Upregulated	Oncogene	Cyclin A1, p21	Proliferation/invasion/migration	[29]
PVT1^↑	Upregulated	Oncogene	EZH2, p15, p16, FOXM1	Proliferation/metastasis	[15, 34]
FEZF1-AS1^↑	Upregulated	Oncogene	LSD1, P21, FEZF1	Proliferation/invasion/migration	[17, 19]
AGAP2-AS1^↑	Upregulated	Oncogene	LSD1, EZH2, P21, E-cadherin	Proliferation/migration/invasion	[31]
XIST^↑	Upregulated	Oncogene	miR-101, EZH2	Proliferation/migration/invasion/growth/metastasis	[32]
ATB^↑	Upregulated	Oncogene	miR-200s, ZEB1, ZEB2	Invasion/EMT	[21]
UCA1^↑	Upregulated	Oncogene	Ets-2, Sox4, miR-204, miR-204-5p, TGFβ1	Migration/invasion/proliferation/apoptosis/chemoresistance/EMT	[64, 66, 96, 97]
NEAT1^↑	Upregulated	Oncogene	Akt, vimentin, N-cadherin, Zo-1, E-cadherin	Proliferation/apoptosis/EMT/migration/invasion	[65, 73]
CCAT2^↑	Upregulated	Oncogene	EZH2, E-cadherin, LATS2	Progression	[39]
CCAT1^↑	Upregulated	Oncogene	c-Myc	Proliferation/migration/invasion	[43]
PANDAR^↑	Upregulated	Oncogene	N-cadherin, vimentin, β-catenin, Snail, Twist, E-cadherin	EMT/growth/migration/invasion/apoptosis	[98]
H19^↑	Upregulated	Oncogene	E-cadherin, Rb-E2F, CDK8, β-catenin, eIF4A3	Migration/invasion/proliferation	[48, 77, 84]
FOXCUT^↑	Upregulated	Oncogene	FOXC1 (mRNA)	Proliferation/migration/invasion	[54]
MALAT1^↑	Upregulated	Oncogene	EZH2, miR-218	Chemoresistance/EMT	[20]
uc002yug.2^↑	Upregulated	Oncogene	RUNX1	Proliferation/migration/invasion	[25]
HOXA11-AS^↑	Upregulated	Oncogene	EZH2, LSD1, miR-1297	Growth/migration/invasion/apoptosis	[16]
CCAL^↑	Upregulated	Oncogene	AP-2α	Progression/multidrug resistance	[11]
GHET1^↑	Upregulated	Oncogene	c-Myc (mRNA)	Proliferation	[18]
ROR^↑	Upregulated	Oncogene	miR-145	Proliferation/migration/invasion	[69]
BC032469^↑	Upregulated	Oncogene	miR-1207-5p	Proliferation	[71]
BLACAT1^↑	Upregulated	Oncogene	EZH2, p15	Proliferation	[72]
GAPLINC^↑	Upregulated	Oncogene	miR211-3p, CD44, PSF, NONO, SNAI2	Invasion	[12, 85]
SPRY4-IT1^↑	Upregulated	Oncogene	Cyclin D1, MMP2, MMP9, E-cadherin, vimentin	Proliferation/migration/invasion/EMT/metastasis	[75, 88]
ZFAS1^↑	Upregulated	Oncogene	EZH2, LSD1, CoREST, KLF2, NKD2	Proliferation	[76]
ANRIL^↑	Upregulated	Oncogene	PRC2, miR-99a, miR-449a	Proliferation	[81]
LINC00152^↑	Upregulated	Oncogene	EZH2, p15, p21	Proliferation	[83]
DUXAP8^↑	Upregulated	Oncogene	EZH2, SUZ12, PLEKHO1	Proliferation/migration	[101]
SNHG15^↑	Upregulated	Oncogene	MMP2, MMP9	Proliferation/migration/invasion	[104]
GAS5^↓	Downregulated	Suppressor	E2F1, P21	Proliferation	[13]
lnc-GNAT1-1^↓	Downregulated	Suppressor	RKIP-NF-κB-Snail	Proliferation/migration/invasion/metastasis	[33]
FER1L4^↓	Downregulated	Suppressor	miR-106a-5p	Proliferation/migration/invasion	[42]
MEG3^↓	Downregulated	Suppressor	p53	Proliferation/apoptosis	[99]
MIR31HG^↓	Downregulated	Suppressor	E2F1, P21	Proliferation	[45]
RP11-766N7.4^↓	Downregulated	Suppressor	Vimentin, N-cadherin, E-cadherin	Migration/invasion/EMT	[26]
FENDRR^↓	Downregulated	Suppressor	FN1, MMP2, MMP9	Migration/invasion	[94]
TUSC7^↓	Downregulated	Suppressor	miR-211-3p	Proliferation	[100]
LINC00982^↓	Downregulated	Suppressor	P15, P16	Proliferation	[103]