Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation

Figure 1

lncRNA SNHG3 was upregulated in lung adenocarcinoma. (a) SNHG3, GAS5, SUMO1P3, and KIAA0125 expression levels in lung adenocarcinoma tissues compared to normal lung tissues from the TCGA database. (b) The relative expression levels of SNHG3 in various human tissues from the NONCODE database. (c) SNHG3 was upregulated in all stages of lung adenocarcinoma compared to normal tissues. (d) SNHG3 was upregulated in lung adenocarcinoma compared to normal tissues by using GSE19804. (e–h) SNHG3 expression levels were correlated with the smoking status, EGFR mutation, TTN mutation, and TP53 mutation. (i) The lncATLAS dataset showed that SNHG3 was located in both the cytoplasm and nucleus. Cytoplasm-located DANCER and nucleus-located NEAT1 were used as positive controls (j). The cellular localization of SNHG3, ACTB, and RNU6 in NSLSC cell lines A549 and H1299. Significance was defined as (, , and ).

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