Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

Table 2

Test performance characteristics of urine markers determined in bladder-derived and upper urinary tract- (UUT-) derived urine.

Test	Source	Tests performed (n)	Positive tests, n	Sensitivity	Specificity	PPV	NPV total
Cytology	Bladder	354	72	59.3	82.9	22.2	96.1
	UUT	379	151	74.6	66.6	29.1	93.4
FISH	Bladder	264	46	52.9	85.0	19.6	96.3
	UUT	171	90	79.0	50.7	16.7	95.1
NMP22	Bladder	240	164	62.5	31.3	6.1	92.1
	UUT	40	38	100.0	5.9	15.8	100.0
uCyt+	Bladder	181	57	50.0	69.8	10.5	95.2
	UUT	10	4	100.0	66.7	25.0	100.0

FISH = fluorescence in situ hybridization; NMP22 = nuclear matrix protein 22; uCyt+ = immunocytology; PPV/NPV = positive/negative predictive value.