Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

Table 3

Sensitivities for detection of upper urinary tract urothelium carcinoma of urine markers determined in bladder-derived and upper urinary tract- (UUT-) derived urine dependent on tumor stage and tumor grade.

Sensitivity [%]	Source	Tumor stage		Tumor grading
		Ta	T1–4	G1/G2	G3/Cis
Cytology	Bladder	43.8	88.9	18.2	92.3
	UUT	65.4	76.9	72.1	78.6
FISH	Bladder	36.4	80.0	28.6	100.0
	UUT	71.4	100.0	73.3	100.0
NMP22	Bladder	50.0	100.0	57.1	75.0
	UUT	100.0	100.0	100.0	100.0
uCyt+	Bladder	25.0	100.0	50.0	66.7
	UUT	100.0	100.0	100.0	100.0

FISH = fluorescence in situ hybridization; NMP22 = nuclear matrix protein 22; uCyt+ = immunocytology; Cis = carcinoma in situ.