Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters

Table 3

Genotype frequencies of α-thalassemia and allelic frequencies of haplotype in SCA patients treated (SCA-HU⁺) and untreated (SCA-HU⁻) with HU.

	SCA-HU^+ patients	SCA-HU^− patients
Tal α^2del 3.7kb			value
αα/αα	23 (85.19%)	51 (78.46%)	0.571
−α/αα	4 (14.81%)	14 (21.54%)
−−/αα	0 (0%)	0 (0%)
Haplotype/chromosome			value
CAR	28 (41.18%)	61 (50%)	—
BEN	36 (52.94%)	51 (41.80%)
ATIP	4 (5.88%)	10 (8.20%)

SCA-HU⁺: SCA patient treated with HU; SCA-HU⁻: SCA patient untreated with HU; N: number; CAR: Bantu; BEN: Benin; ATIP: atypical. Exact Fischer test.