Cell-Free Circulating Methylated SEPT9 for Noninvasive Diagnosis and Monitoring of Colorectal Cancer

Table 4

Correlations between plasma mSEPT9 and clinicopathologic characteristics of CRC patients.

Characteristics	Case	mSEPT9 positive case		value
	N	N	%
All cases	98	60	61.2
Gender
Male	61	33	54.1	0.063
Female	37	27	73.0
Age (years)
≤60	38	21	55.3	0.335
>60	60	39	65.0
Tumor size (cm)
≤5	58	30	51.7	0.038
	22	17	77.3
Unknown	18	13	72.2
Location
Colon	18	14	77.8	0.111
Rectum	80	46	57.5
General histological type
Ulcerative	45	31	68.9	0.005
Protrude	24	8	33.3
Others	3	1	33.3
Unknown	26	20	76.9
Histological grade
1 + 2	66	34	51.5	0.046
3 + 4	24	18	75.0
Unknown	8	8	100.0
Stage
0	3	1	33.3	0.376
I	23	11	47.8
II	31	19	61.3
III	31	20	64.5
IV	8	7	87.5
Intravascular tumor thrombus
Negative	25	18	72.0	0.055
Positive	57	28	49.1
Unknown	16	14	87.5
Nerve invasion
Negative	34	23	67.6	0.187
Positive	22	11	50.0
Unknown	16	11	68.8

: mSEPT9 in ulcerative CRC versus protrude CRC.