Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome

Table 2

The Cox regression model for death at 6 and 12 months.

Characteristic	At six months			At one year
	HR	95% CI	value	HR	95% CI	value
Copeptin ≥ 17.4 pmol/l	14.1	1.7–116.8	0.01	4.3	1.3–14.8	0.02
Age	1.3	1.1–1.5	0.001	1.1	1.04–1.2	0.002
Male sex	0.2	0.04–1.1	0.06	0.6	0.2–1.9	0.359
Diagnosis of NSTEMI	3.0	0.4–24.7	0.31	2.3	0.5–10.8	0.281
Prior AMI	1.0	0.2–5.0	0.96	1.4	0.4–4.8	0.591
Diabetes mellitus	1.1	0.2–5.8	0.89	1.1	0.3-4.1	0.909
GFR	0.9	0.86–0.95	<0.001	0.99	0.9–0.95	<0.001
EF	1.0	0.9–1.0	0.09	0.95	0.9–0.99	0.026
Admission NYHA class 3 or 4	7.7	1.3–46.1	0.03	11.8	1.9–72	0.008
Hs-TnT ≥ 14 ng/l at admission	33.6	0.03–366,658	0.33	4.1	0.5–32.3	0.176
Hs-TnT mx	1.0	0.99–1.0	0.82	1.0	0.99–1.0	0.642

AMI: acute myocardial infarction; CI: confidence interval; EF: ejection fraction; GFR: glomerular filtration ratio; GRACE: Global Registry of Acute Coronary Events; HR: hazard ratio; hs-TnT mx: maximal concentration of high-sensitive troponin T; NSTEMI: non-ST segment elevation myocardial infarction; NYHA: New York Heart Association.