Novel Biomarker Candidates for Febrile Neutropenia in Hematological Patients Using Nontargeted Metabolomics

Figure 2

The most differential metabolites and their changes on day 0 (d0) and day 1 (d1) from beginning of the febrile neutropenia. (a) Androsterone sulfate (ADTS)/dihydrotestosterone sulfate (DHTS), (b) citrulline, (c) phosphatidylethanolamine PE(18:0/20:4), (d) phosphatidylcholine PC(15:0/22:6), (e) phosphatidylcholine PC(16:0/20:4), and (f) phosphatidylcholine PC(16:0/22:6). “No” indicates patients without complicated course of febrile neutropenia. “Yes” indicates patients with complicated course of febrile neutropenia. Day 0 indicates the onset of febrile neutropenia. Day 1 indicates the next day. Horizontal line represents median, box encompasses 25th and 75th percentiles, and error bar encompasses 10th and 90th percentiles.

(a)

(b)

(c)

(d)

(e)

(f)