Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy’s Pathogenesis

Figure 2

Immunohistochemistry for the ER stress markers in clinical forms I, TT, and LL of leprosy. Note that positive labeling is characterized by a brownish cytoplasmic pattern on granuloma cells (400x). (d) Indeterminate leprosy, GRP78/BiP antibody; (e) tuberculoid leprosy, GRP78/BiP antibody; (f) lepromatous leprosy, GRP78/BiP antibody; (j) indeterminate leprosy, PERK antibody; (k) tuberculoid leprosy, PERK antibody; (l) lepromatous leprosy, PERK antibody; (g) indeterminate leprosy, IRE1α antibody; (h) tuberculoid leprosy, IRE1α antibody; (i) lepromatous leprosy, IRE1α antibody; (a) indeterminate leprosy, ATF6 antibody; (b) tuberculoid leprosy, ATF6 antibody; (c) lepromatous leprosy, ATF6 antibody.