Endoplasmic Reticulum Stress Markers and Their Possible Implications in Leprosy’s Pathogenesis

Table 1

Quantitative analysis of GRP78/BiP, PERK, IRE1α, and ATF6 levels according to the clinical form of leprosy.

Markers	Clinical form of leprosy			value
	I; Mean ± SD (95% CI)	TT; Mean ± SD (95% CI)	LL; Mean ± SD (95% CI)
GRP78/BiP	8.96 ± 3.15 (7.05–10.86)	13.84 ± 3.90 (11.68–16.00)	10.41 ± 2.57 (8.99–11.84)	0.0009
PERK	7.49 ± 2.61 (5.92–9.07)	13.33 ± 3.68 (11.30–15.37)	12.48 ± 3.77 (10.39–14.57)	0.0001
IRE1α	7.34 ± 2.17 (6.03–8.65)	12.21 ± 2.35 (10.91–13.51)	7.84 ± 1.14 (7.21–8.47)	<0.0001
ATF6	7.48 ± 1.77 (6.41–8.55)	10.11 ± 2.38 (8.79–11.42)	6.93 ± 1.77 (5.96–7.91)	0.0002

I: indeterminate; LL: lepromatous; TT: tuberculoid; 95% CI: 95% confidence interval; SD: standard deviation. Ordinary one-way ANOVA (). Statistically significant.