A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients
Table 2
Stratified analyses of MMP1–1607 (1G>2G) polymorphism on cancer risks by random-effects model.
2g vs. 1g
2g2g–1g2g vs. 1g1g
2g2g vs. 1g1g–1g2g
OR
UCI
LCI
OR
UCI
LCI
OR
UCI
LCI
Overall
77
1.174
1.107
1.244
0.000
74.0%
1.192
1.090
1.303
0.000
62.4%
1.231
1.141
1.329
0.000
67.5%
Cancer types
Lung cancer
9
1.128
1.002
1.269
0.006
63.1%
1.127
1.005
1.264
0.365
8.4%
1.153
0.953
1.395
0.002
68.1%
Colorectal cancer
8
1.279
1.087
1.505
0.035
53.6%
1.281
1.033
1.588
0.365
8.5%
1.368
1.094
1.712
0.041
52.1%
Gastric cancer
6
1.106
0.964
1.268
0.165
36.3%
1.221
0.884
1.687
0.061
52.6%
1.121
0.967
1.300
0.448
0.0%
Oral cancer
6
1.121
0.849
1.481
0.000
81.8%
1.254
0.790
1.991
0.001
75.9%
1.108
0.807
1.521
0.003
72.3%
Nervous system cancer
5
1.799
1.493
2.168
0.869
0.0%
2.070
1.474
2.906
0.438
0.0%
1.935
1.498
2.501
0.475
0.0%
Ovarian cancer
4
1.022
0.888
1.176
0.845
0.0%
1.090
0.769
1.545
0.174
39.7%
1.013
0.823
1.247
0.417
0.0%
Breast cancer
4
1.194
0.904
1.576
0.000
89.6%
1.352
0.906
2.017
0.000
84.9%
1.149
0.809
1.632
0.000
84.7%
Renal cancer
4
1.351
1.149
1.590
0.328
12.8%
1.179
0.898
1.547
0.829
0.0%
1.674
1.351
2.073
0.580
0.0%
Bladder cancer
4
1.437
0.960
2.152
0.000
89.2%
1.349
0.771
2.360
0.001
83.1%
1.739
1.074
2.816
0.001
81.7%
Prostate cancer
4
0.932
0.485
1.791
0.000
90.3%
1.136
0.493
2.616
0.001
82.5%
0.780
0.375
1.623
0.001
82.3%
Head and neck cancer
4
0.958
0.595
1.543
0.000
92.6%
0.678
0.388
1.186
0.001
81.1%
1.071
0.539
2.219
0.000
92.4%
Endometrial cancer
3
1.147
0.756
1.741
0.020
74.4%
1.312
0.492
3.497
0.005
81.0%
1.091
0.807
1.476
0.320
12.3%
Nasopharyngeal cancer
3
1.212
1.067
1.377
0.340
7.4%
1.299
0.996
1.696
0.319
12.5%
1.265
1.074
1.488
0.535
0.0%
Hepatocellular cancer
3
0.995
0.875
1.131
0.890
0.0%
0.816
0.631
1.055
0.333
9.0%
1.118
0.932
1.341
0.428
0.0%
Esophageal cancer
3
1.189
0.899
1.572
0.039
69.1%
1.321
0.908
1.922
0.138
49.5%
1.260
0.866
1.835
0.080
60.4%
Other cancers
7
1.172
1.010
1.360
0.043
53.8%
1.128
0.903
1.410
0.167
34.2%
1.278
1.038
1.573
0.073
48.0%
Ethnicity
Asian
43
1.228
1.130
1.334
0.009
75.2%
1.256
1.084
1.456
0.000
68.9%
1.297
1.176
1.431
0.000
66.4%
Caucasian
34
1.109
1.023
1.202
0.009
71.2%
1.126
1.015
1.249
0.000
50.1%
1.431
1.013
1.289
0.000
67.2%
n: number of comparison; P: value of test for heterogeneity test; UCI: upper limit of the 95% confidence interval; LCI: lower limit of the 95% confidence interval.
