Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery
Table 4
Multivariable linear regression model with maternal and cord blood irisin levels as dependent variables.
Variable
Reference category
Comparative category
Mother
Infant
β
95% CI
value
β
95% CI
value
PTB status
Term
Preterm
−0.026
(−0.227; 0.175)
0.796
0.212
(−0.059; 0.483)
0.122
Maternal age
−0.003
(−0.016; 0.010)
0.649
0.000
(−0.017; 0.016)
0.958
Preconception BMI
−0.001
(−0.011; 0.010)
0.915
0.000
(−0.013; 0.013)
0.955
Gestational age
0.001
(−0.022; 0.024)
0.935
0.008
(−0.022; 0.038)
0.591
Primiparity
No
Yes
−0.130
(−0.257; −0.002)
0.046
−0.030
(−0.195; 0.136)
0.718
Smoking status
Nonsmoker
Smoker + former smoker
0.017
(−0.161; 0.194)
0.852
−0.176
(−0.371; 0.019)
0.076
Education status
Primary
Secondary
−0.024
(−0.158; 0.110)
0.719
0.067
(−0.105; 0.238)
0.437
University
0.045
(−0.101; 0.191)
0.536
0.083
(−0.098; 0.263)
0.361
Infection
No
Yes
0.001
(−0.121; 0.124)
0.982
0.055
(−0.103; 0.214)
0.485
Infant gender
Women
Men
−0.063
(−0.172; 0.046)
0.251
−0.012
(−0.158; 0.135)
0.873
rs16835198
GG
GT
0.032
(−0.095; 0.159)
0.613
0.157
(−0.007; 0.321)
0.061
TT
0.178
(−0.040; 0.396)
0.106
rs726344
GG
GA + AA
0.035
(−0.084; 0.154)
0.555
−0.140
(−0.298; 0.019)
0.082
rs3480
AA
AG
−0.081
(−0.225; 0.064)
0.267
0.082
(−0.109; 0.273)
0.389
GG
−0.093
(−0.282; 0.096)
0.327
0.181
(−0.104; 0.467)
0.207
rs1746661
GG
GT + TT
0.117
(−0.030; 0.264)
0.116
−0.001
(−0.154; 0.153)
0.992
In the multivariable linear regression model, maternal and cord blood irisin concentrations were investigated in relation to the 13 variables listed in the table. In the case of categorical variables, a reference category was selected and compared with one or two other categories. As only a few cases of TT and AA homozygotes were identified (in rs726344 and rs1746661, resp.), analysis was performed as A (GG versus GA + AA) and T (GG versus GT + TT) dominant models and the genotype categories were merged. Significant results are in bold. GG versus GT + TT (T dominant model).
