Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study

Table 2

Clinical, respiratory, and biological parameters at ICU admission. Data are presented as median [interquartile range]. ICU: intensive care unit; PBW: predicted body weight; FiO₂: fraction of inspired oxygen; PaO₂: arterial partial pressure of oxygen; PaCO₂: arterial partial pressure of carbon dioxide; CRP: C-reactive protein. PINI: prognostic nutritional and inflammatory index; RAGE: receptor for advanced glycation end products; sRAGE: soluble RAGE; esRAGE: endogenous secretory RAGE.

Clinical parameters
Heart rate (bpm)	86.5 [70.3–104]
Mean arterial pressure (mmHg)	78 [69–88]
Respiratory rate (cpm)	17 [14–21]
Temperature (°C)	37.0 [36.5–37.4]
Glasgow coma scale	10.5 [0–15]
Respiratory parameters
Tidal volume (mL)	472.5 [440.5–510]
Tidal volume (mL·kg^−1 of PBW)	7.4 [6.7–8.1]
Positive end-expiratory pressure (cmH2O)	7 [6–8]
Inspiratory plateau pressure (cmH2O)	17 [14–20]
FiO2 (%)	36 [28–50]
PaO2 (mmHg)	92 [77–132.8]
PaCO2 (mmHg)	37 [32–43.8]
pH	7.4 [7.3–7.4]
Serum bicarbonate (mmol·L^−1)	21 [18–24]
PaO2/FiO2	250 [154.3–300]
Biological parameters
Serum creatinine (μmol·L^−1)	76 [56–115]
Serum urea (mmol·L^−1)	6.6 [4.3–10]
Serum sodium (mmol·L^−1)	139.5 [136–142]
Serum potassium (mmol·L^−1)	3.9 [3.6–4.2]
Blood leucocytes (G·L^−1)	11.6 [8.1–16.6]
Blood platelets (G·L^−1)	185 [113–247]
CRP (mg·L^−1)	108 [35.5–182]
Serum lactate (mmol·L^−1)	1.6 [0.9–2.8]
Serum orosomucoid (g·L^−1)	1.3 [0.9–1.9]
Serum prealbumin (g·L^−1)	0.1 [0.1–0.2]
Serum albumin (g·L^−1)	26.1 [22–30.9]
PINI	36.8 [8.6–167.9]
RAGE soluble forms
sRAGE (pg·mL^−1)	1006 [638–1993]
esRAGE (pg·mL^−1)	470 [202–1000]