Prognostic Factors and Survival in Primary Central Nervous System Lymphoma: A Population-Based Study
Table 5
Univariate and multivariate survival analysis in immunocompetent patients with non-DLBCL.
Variable
Univariate analysis
Multivariate analysis
HR (95% CI)
HR (95% CI)
Age (years)
<60
Reference
Reference
≥60
2.399 (2.085–2.759)
<0.001
2.389 (2.052–2.780)
<0.001
Race
White
Reference
Black
0.777 (0.608–0.993)
0.043
Other (American Indian/AK native, Asian/Pacific Islander)
1.016 (0.793–1.300)
0.902
Gender
Female
Reference
0.946
Male
1.005 (0.880–1.147)
Dates of diagnosis
1973–1984
Reference
1985–1995
1.165 (0.876–1.549)
0.294
1996–2006
0.761 (0.577–1.002)
0.052
2007–2014
0.847 (0.633–1.135)
0.266
Primary Site
Brain
Reference
Reference
Meninges/cranial nerves
0.358 (0.245–0.524)
<0.001
0.349 (0.238–0.511)
<0.001
Spine
0.443 (0.355--0.553)
<0.001
0.452 (0.362–0.565)
<0.001
Other
0.555 (0.463–0.666)
<0.001
0.515 (0.428–0.618)
<0.001
Laterality
Not a paired site
Reference
Paired site (left/right—origin of primary)
0.962 (0.804–1.150)
0.670
Lymphoma Ann Arbor stage
I–II
Reference
III–IV
0.980 (0.835–1.152)
0.810
Unknown
1.008 (0.832–1.220)
0.936
Radiation
No
Reference
Yes
0.894 (0.780–1.023)
0.104
Unknown
1.978 (1.198–3.267)
0.008
Chemotherapy
No
Reference
Reference
Yes
0.684 (0.599–0.781)
<0.001
0.724 (0.633–0.828)
<0.001
Insurance status
Uninsured
Reference
Insured/any Medicaid
1.457 (0.685–3.096)
0.328
Insurance status unknown
1.522 (0.722–3.208)
0.270
Marital status
Never married
Reference
Reference
Married
1.153 (0.961–1.383)
0.126
0.821 (0.677–0.994)
0.043
Ever married (divorced, separated, and widowed)
1.689 (1.363–2.094)
<0.001
1.048 (0.833–1.319)
0.689
Unknown
1.206 (0.805–1.805
0.364
0.809 (0.538–1.217)
0.309
OS: overall survival; HR: hazard ratio; CI: confidence interval; SEER: Surveillance, Epidemiology, and End Results; DLBCL: diffuse large B cell lymphoma; PCNSL: primary central nervous system lymphoma.