Research Article
Polymorphisms in Vitamin D Receptor Genes in Association with Childhood Autism Spectrum Disorder
Table 2
Distribution of SNP genotypes and allele frequencies among children with ASD and controls.
| | SNPs | Genotype/allele | Cases
n (%) | Controls
n (%) | OR | 95% CI | value |
| | rs731276 | | | TT | 170 (84.6) | 183 (91.5) | 1 | | | | CT | 31 (15.4) | 17 (8.5) | 1.96 | 1.05–1.3.68 | 0.0351 | | T | 371 (92.3) | 383 (95.7) | 1 | | | | C | 31 (7.7) | 17 (4.3) | 1.88 | 1.02–3.46 | 0.0416 |
| | rs1568820 | | | GG | 76 (38.2) | 68 (34.2) | 1 | | | | GA | 86 (43.2) | 96 (48.2) | 0.80 | 0.52–1.24 | 0.3225 | | AA | 37 (18.6) | 35 (17.6) | 0.95 | 0.54–1.67 | 0.8472 | | G | 238 (59.8) | 232 (58.3) | 1 | | | | A | 160 (40.2) | 166 (41.7) | 0.94 | 0.71–1.25 | 0.6654 |
| | rs1544410 | | | GG | 177 (88.1) | 178 (89.9) | 1 | | | | GA | 24 (11.9) | 20 (10.1) | 1.20 | 0.64–2.26 | 0.5590 | | G | 378 (94.0) | 376 (95.0) | 1 | | | | A | 24 (6.0) | 20 (5.0) | 1.19 | 0.65–2.20 | 0.5708 |
| | rs2228570 | | | TT | 53 (26.6) | 40 (20.3) | 1 | | | | CT | 99 (49.8) | 104 (26.9) | 0.72 | 0.44–1.18 | 0.1897 | | CC | 47 (23.6) | 53 (52.8) | 0.67 | 0.38–1.18 | 0.1659 | | T | 205 (51.5) | 184 (46.7) | 1 | | | | C | 193 (48.5) | 210 (53.3) | 0.83 | 0.62–1.09 | 0.1766 |
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∗Number of cases and controls varied because some samples were unable to be genotyped.
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