Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Figure 2

Forest plots of the studies that evaluated the hazard ratios of high vs. low miRNA expression. (a) Forest plot of the relationship between various miRNA expression and overall survival (OS) in NSCLC patients included in the meta-analysis. (b) Forest plot of the survival data reported in the studies with paired tissue samples (cancerous and adjacent noncancerous) as the source of miRNAs. (c) Forest plot of the survival data reported in the studies based on liquid biopsy samples as a source of miRNAs. (d) Forest plot of survival data from Asia. (e) Forest plot of survival data from Europe. (f) Forest plot of survival data from America. (g) Forest plot of the relationship between high miRNA-21 expression and overall survival in cancer patients with both random and fixed effects model. (h) Forest plot of the included studies that evaluated the hazard ratio of high miRNA-155 expression vs. low expression. (i) Forest plot of the relationship between lower miRNA-let-7 expression and OS in selected studies. (j) Forest plot of survival data for low miRNA-148a expression. (k) Forest plot of survival data for low miRNA-148b expression and OS in NSCLC studies.

(a) Overall studies

(b) Paired tissue samples

(c) Liquid biopsy samples

(d) Asian studies

(e) European studies

(f) American studies

(g) miRNA-21

(h) miRNA-155

(i) miRNA-let-7

(j) miRNA-148a

(k) miRNA-148b