Serum Cytokine Profiles in Patients with Dengue Fever at the Acute Infection Phase
Table 3
Concentration of inflammatory cytokines in infections and controls.
Primary infection (mean ± SD)
P value
Secondary infection (mean ± SD)
P value
Control (E) (mean ± SD)
P value
1st week (A)
2nd week (B)
A versus E
B versus E
1st week (C)
2nd week (D)
C versus E
D versus E
A versus C
B versus D
Number of case
152
82
—
—
44
19
20
CXCL9 (MIG)
238.61 ± 265.29
625.52 ± 700.20
<0.001
<0.001
710.20 ± 1435.59
802.32 ± 644.12
<0.001
<0.001
58.35 ± 100.68
0.001
0.225
CCL17 (TARC)
303.26 ± 490.43
220.40 ± 209.15
<0.001
<0.001
151.09 ± 155.53
468.16 ± 926.50
<0.001
0.001
855.40 ± 442.74
0.009
0.537
CXCL5 (ENA-78)
875.13 ± 1553.74
786.72 ± 649.12
<0.001
<0.001
695.59 ± 833.55
1209.47 ± 804.15
<0.001
0.002
2320.05 ± 1237.33
0.229
0.018∗
CCL11 (eotaxin)
341.20 ± 209.82
362.48 ± 233.38
0.385
0.604
307.23 ± 142.02
468.58 ± 163.38
0.389
0.032
375.65 ± 215.28
0.841
0.002∗∗
IP-10
7694.73 ± 5035.07
6382.49 ± 4539.37
<0.001
<0.001
7387.52 ± 4874.71
7335.05 ± 6475.22
<0.001
<0.001
367.60 ± 151.43
0.672
0.962
CXCL11 (I-TAC)
4116.99 ± 2659.76
1424.44 ± 1184.22
<0.001
<0.001
3725.09 ± 3105.49
1214.58 ± 1088.54
<0.001
<0.001
254.50 ± 531.58
0.199
0.326
IL-8
1911.43 ± 4409.65
1226.95 ± 2478.91
<0.001
0.004
2407.39 ± 5175.86
1793.00 ± 2336.76
<0.001
0.002
958.70 ± 2112.73
0.616
0.098
IL-10
45.88 ± 61.41
11.16 ± 11.80
<0.001
<0.001
60.11 ± 81.01
7.58 ± 5.07
<0.001
<0.001
1.50 ± 0.61
0.240
0.280
CCL2 (MCP-1)
9768.83 ± 9708.82
5807.54 ± 3414.33
<0.001
<0.001
8611.84 ± 6343.42
8009.00 ± 10517.43
<0.001
<0.001
2427.95 ± 845.28
0.809
0.339
IFN-γ
251.03 ± 917.31
15.05 ± 36.22
<0.001
<0.001
93.39 ± 152.62
7.79 ± 15.62
<0.001
0.054
0.35 ± 1.57
0.226
0.136
IL-18
205.80 ± 221.93
198.98 ± 211.30
0.005
0.047
286.20 ± 397.11
141.05 ± 115.95
0.029
0.325
105.45 ± 55.26
0.834
0.364
MIP-1α
244.68 ± 398.14
253.67 ± 431.30
0.006
0.003
223.41 ± 262.85
210.26 ± 157.82
0.156
0.002
127.20 ± 142.06
0.392
0.633
RANTES
11621.99 ± 4007.26
16017.28 ± 3794.66
<0.001
0.214
11632.41 ± 4207.56
17477.47 ± 3340.15
<0.001
0.933
17165.85 ± 2359.73
0.819
0.200
MIP-1β
196.97 ± 180.47
145.11 ± 188.44
0.237
0.511
165.84 ± 128.60
128.05 ± 100.70
0.845
0.491
146.85 ± 97.90
0.214
0.677
CCL20 (MIP-3α)
46.79 ± 198.24
21.38 ± 63.88
0.318
0.517
19.66 ± 27.61
15.84 ± 18.98
0.976
0.942
56.05 ± 178.53
0.212
0.401
Mean ± SD of cytokines were presented and performed analysis using Mann–Whitney U test or t-test between two cohorts. Statistical significance is indicated by asterisks: or .
