Disease Markers / 2018 / Article / Tab 2

Research Article

ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population

Table 2

Genotype frequency distribution of ABCC4 in KD patients and healthy controls.

GenotypePatients ()Controls () valueaOR (95% CI) valueAdjusted OR (95% CI) valueb

ABCC4/rs7986087 C > T (HWE = 0.5938)
CC488 (62.97)530 (68.48)0.01971.0001.000
CT257 (33.16)207 (26.74)1.35 (1.08–1.68)0.00791.37 (1.09–1.70)0.0057
TT30 (3.87)37 (4.78)0.88 (0.54–1.45)0.61600.90 (0.55–0.48)0.6794
Dominant287 (37.03)244 (31.52)0.02231.28 (1.03–1.58)0.02251.30 (1.05–1.60)0.0161
Recessive745 (96.13)737 (95.22)0.07860.80 (0.49–1.31)0.38150.82 (0.50–1.34)0.4193
ABCC4/rs3742106 A > C (HWE = 0.8429)
AA171 (22.06)191 (24.68)0.16181.0001.000
AC389 (50.19)399 (51.55)1.09 (0.85–1.40)0.50261.09 (0.85–1.40)0.4829
CC215 (27.74)184 (23.77)1.30 (0.98–1.74)0.06721.32 (0.99–1.76)0.0547
Dominant604 (77.93)583 (75.32)0.22431.16 (0.91–1.46)0.22501.17 (0.92–1.48)0.2032
Recessive560 (72.25)590 (76.23)0.07401.23 (0.98–1.55)0.07471.25 (0.99–1.57)0.0608
ABCC4/rs9561778 G > T (HWE = 0.3799)
GG381 (49.16)410 (52.97)0.27791.0001.000
GT332 (42.84)312 (40.31)1.14 (0.93–1.41)0.20231.14 (0.93–1.41)0.2147
TT62 (8)52 (6.72)1.28 (0.86–1.90)0.21601.25 (0.84–1.86)0.2625
Dominant394 (50.84)364 (47.03)0.13361.16 (0.95–1.42)0.13391.16 (0.95–1.41)0.1519
Recessive713 (92)722 (93.28)0.33381.21 (0.82–1.77)0.33581.18 (0.80–1.73)0.3950
ABCC4/rs1751034 C > T (HWE = 0.6842)
CC36 (4.65)34 (4.39)0.82561.0001.000
CT271 (34.97)282 (36.43)0.91 (0.55–1.49)0.70260.94 (0.57–1.56)0.8223
TT468 (60.39)458 (59.17)0.96 (0.59–1.57)0.88601.01 (0.61–1.63)0.9932
Dominant739 (95.36)740 (95.6)0.81100.94 (0.58–1.52)0.81110.98 (0.60–1.59)0.9346
Recessive307 (39.62)316 (40.82)0.62621.05 (0.86–1.29)0.62611.05 (0.86–1.29)0.6104
ABCC4/rs3765534 C > T (HWE = 0.5252)
CC701 (90.45)677 (87.47)0.16891.0001.000
CT73 (9.42)96 (12.4)0.73 (0.53–1.01)0.06040.74 (0.53–1.02)0.0666
TT1 (.13)1 (.13)0.97 (0.06–15.47)0.98040.73 (0.04–12.14)0.8294
Dominant74 (9.55)97 (12.53)0.06060.74 (0.53–1.01)0.06170.74 (0.54–1.02)0.0650
Recessive774 (99.87)773 (99.87)0.99931.00 (0.06–16.02)1.00000.75 (0.04–12.43)0.8421
ABCC4/rs868853 C > T (HWE = 0.2545)
CC18 (2.32)18 (2.33)0.02561.0001.000
CT228 (29.42)181 (23.39)1.26 (0.64–2.49)0.50701.28 (0.65–2.54)0.4749
TT529 (68.26)575 (74.29)0.92 (0.47–1.79)0.80560.92 (0.48–1.80)0.8190
Dominant757 (97.68)756 (97.68)0.99691.00 (0.52–1.94)0.99691.01 (0.52–1.96)0.9764
Recessive246 (31.74)199 (25.72)0.00870.74 (0.59–0.93)0.00880.74 (0.59–0.92)0.0067
Combined effect of risk genotypes
0–4691 (89.16)722 (93.28)1.0001.000
5-684 (10.84)52 (6.72)0.00401.63 (1.07–2.47)0.02171.63 (1.07–2.47)0.0229

aχ2 test for genotype distributions between Kawasaki disease patients and controls; badjusted for age and gender.

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