Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma

Table 2

Univariate and multivariate Cox regression analysis for OS in lung adenocarcinoma patients.

Variates	Categories	Univariate analysis		Multivariate analysis
		HR (95%CI)	value	HR (95%CI)	value
Gender	Male versus female	1.361 (0.843–2.199)	0.207
Age	>60 versus ≤60 years	1.058 (0.654–1.711)	0.818
Differentiation	Poor versus well/moderate	1.025 (0.602–1.746)	0.927
pT	T3-4 versus T1-2	1.393 (0.771–2.516)	0.272
pN	N1-3 versus N0	2.767 (1.697–4.512)	<0.001	2.770 (1.642–4.674)	<0.001
TNM stage	II-III versus I	2.474 (1.517–4.036)	<0.001
MAP4 expression	High versus low	1.714 (1.060–2.771)	0.028	1.655 (1.017–2.692)	0.042

OS: overall survival; HR: hazard ratio; CI: confidence interval; p: pathological staging; TNM: tumor-node-metastasis; MAP4: microtubule-associated protein 4.