Differential Expression of TXNIP Isoforms in the Peripheral Leukocytes of Patients with Acute Myocardial Infarction

Figure 1

Comparison of difference between TXNIP1 and TXNIP2 coding sequences. NCBI data showed that the TXNIP gene was located on the complementary strand of chromosome 1 (1q21.1, 145992426-145996631, a total of 4206 base pairs), including 8 exons. The exons/CDS with different filling patterns represent the different regions of the two isoforms. The solid arrows represent the position of the forward primers, and the hollow arrows represent the position of the reverse primers. The two forward primers share the same reverse primer. The coding region A contains 250 bases, and the coding region B contains 85 bases. Except for the last base, the nucleotide sequences of the two regions are completely different. That is to say, there are differences in amino acid length and sequence between the N terminal (83 amino acids) of TXNIP1 and the N terminal (28 amino acids) of TXNIP2.