Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children
Table 2
Association of hematological parameters with variant allele of CYP2E1 -1293G>C/-1053C>T and NQO1 609C>T polymorphisms in both leukopenic and control children.
Hematological parameters
Presence of the CYP2E1 variant allele c2
Presence of the NQO1 variant allele T
Leukopenic (3)
Controls (6)
Leukopenic (17)
Controls (26)
Mean ± SD
Mean ± SD
Mean ± SD
Mean ± SD
RBC (×106/mL)
4.56 ± 0.09
4.59 ± 0.07
0.7843
4.67 ± 0.09
4.57 ± 0.07
0.3092
Hemoglobin (g/dL)
13.10 ± 0.26
13.25 ± 0.19
0.6663
13.31 ± 0.19
12.82 ± 0.19
0.0848
Hematocrit (%)
39.13 ± 1.13
39.33 ± 0.25
0.8151
39.71 ± 0.65
38.43 ± 0.51
0.1268
RDW (%)
14.60 ± 0.90
14.37 ± 0.28
0.7559
14.73 ± 0.24
14.86 ± 0.19
0.6736
WBC (×103/mL)
3.45 ± 0.20
8.23 ± 1.43
0.0449
3.58 ± 0.10
6.58 ± 0.25
<0.0001
Neutrophils (×103/mL)
1.04 ± 0.22
4.10 ± 0.96
0.0671
1.13 ± 0.06
2.79 ± 0.19
<0.0001
Eosinophils (×103/mL)
0.17 ± 0.05
0.54 ± 0.11
0.0655
0.23 ± 0.03
0.43 ± 0.05
0.0059
Basophils (×103/mL)
0.04 ± 0.02
0.08 ± 0.01
0.2062
0.06 ± 0.007
0.07 ± 0.004
0.1333
Lymphocytes (×103/mL)
1.91 ± 0.08
2.92 ± 0.28
0.0461
1.83 ± 0.06
2.85 ± 0.15
<0.0001
Monocytes (×103/mL)
0.28 ± 0.01
0.59 ± 0.11
0.0944
0.33 ± 0.02
0.42 ± 0.02
0.0024
Platelets (×103/mL)
233.67 ± 15.34
299.83 ± 38.24
0.2828
263.76 ± 11.62
304.96 ± 16.96
0.0811
Uric acid (mg/dL)
3.267 ± 1.007
4.133 ± 0.5989
0.1667
3.92 ± 0.99
4.31 ± 0.73
0.1194
Total cholesterol (mg/dL)
169.7 ± 17.62
204.5 ± 82.21
0.6190
172.6 ± 40.27
166.00 ± 34.64
0.4639
HDL-c (mg/dL)
39.00 ± 3.606
40.67 ± 7.528
>0.9999
41.35 ± 10.85
42.38 ± 10.17
0.6443
LDL-c (mg/dL)
111.8 ± 20.44
146.1 ± 75.91
0.6190
113.30 ± 31.73
108.40 ± 30.32
0.5345
Triglycerides (mg/dL)
94.33 ± 77.73
88.83 ± 48.80
0.7619
89.88 ± 49.42
76.08 ± 30.14
0.5588
Creatinine (mg/dL)
0.5167 ± 0.1305
0.6000 ± 0.1161
0.5000
0.76 ± 0.28
0.70 ± 0.176
0.9265
Free iron (mg/dL)
91.00 ± 22.61
80.33 ± 18.70
0.5476
98.82 ± 37.05
83.85 ± 36.84
0.1965
Glucose (mg/dL)
97.00 ± 9.539
100.7 ± 9.092
0.7619
91.24 ± 11.13
97.69 ± 9.35
0.0805
Urea (mg/dL)
29.67 ± 10.07
22.00 ± 6.870
0.4286
23.71 ± 7.69
22.42 ± 6.78
0.7629
SD: standard deviation; RBC: red blood cell; RDW: red cell distribution width; WBC: white blood cell; HDL-c: high-density lipoproteins of cholesterol; LDL-c: low-density lipoproteins of cholesterol.
