Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children
Table 3
Association of hematological parameters with variant allele of polymorphisms in MPO -463G>A in both leukopenic and control children.
Hematological parameters
Presence of the MPO variant allele A
Leukopenic (17)
Controls (34)
Mean ± SD
Mean ± SD
RBC (×106/mL)
4.67 ± 0.07
4.70 ± 0.04
0.721
Hemoglobin (g/dL)
13.17 ± 0.21
12.96 ± 0.11
0.344
Hematocrit (%)
39.36 ± 0.57
38.76 ± 0.33
0.335
RDW (%)
14.81 ± 0.23
14.95 ± 0.15
0.617
WBC (×103/mL)
3.69 ± 0.07
6.96 ± 0.28
<0.0001
Neutrophils (×103/mL)
1.17 ± 0.07
3.03 ± 0.21
<0.0001
Eosinophils (×103/mL)
0.27 ± 0.04
0.50 ± 0.07
0.032
Basophils (×103/mL)
0.05 ± 0.007
0.08 ± 0.005
0.002
Lymphocytes (×103/mL)
1.87 ± 0.06
2.86 ± 0.12
<0.0001
Monocytes (×103/mL)
0.34 ± 0.02
0.48 ± 0.02
0.0007
Platelets (×103/mL)
247.18 ± 11.12
318.56 ± 15.55
0.004
Uric acid (mg/dL)
4.035 ± 1.001
4.282 ± 0.7505
0.3275
Total cholesterol (mg/dL)
158.6 ± 34.21
178.0 ± 44.54
0.3642
HDL-c (mg/dL)
39.94 ± 11.66
43.29 ± 8.476
0.1023
LDL-c (mg/dL)
103.1 ± 28.83
119.5 ± 41.59
0.4913
Triglycerides (mg/dL)
78.12 ± 42.23
76.15 ± 31.95
0.6958
Creatinine (mg/dL)
0.7853 ± 0.354
0.6503 ± 0.177
0.1614
Free iron (mg/dL)
107.6 ± 37.59
87.15 ± 38.22
0.018
Glucose (mg/dL)
94.76 ± 9.291
96.97 ± 9.233
0.3229
Urea (mg/dL)
23.12 ± 6.790
23.15 ± 6.378
0.7776
SD: standard deviation; RBC: red blood cell; RDW: red cell distribution width; WBC: white blood cell; HDL-c: high-density lipoproteins of cholesterol; LDL-c: low-density lipoproteins of cholesterol.
