Variables Mild ( ) Medium ( ) Severe ( ) Gravis ( ) valueMale, n (%) 39 (67.2) 53 (70.7) 36 (81.8) 66 (79.5) 0.209 Age, years 43 (30.5) 42 (23) 48. 5(27.25) 49 (20) 0.105 Max temperature, °C 38.8 (1.42) 39 (1.60) 39 (1.27) 39 (1.3) 0.140 Admitted days after fever, days 5 (3.00) 5 (3.00) 6 (2.00) 5 (3.00) 0.070 SBP, mmHg 120 (17.25) 121 (23) 125 (29.5) 117 (19) 0.058 DBP, mmHg 76 (14) 77 (15) 83.5 (20.50) 77 (16) 0.177 Smoking, n (%) 20 (34.5) 30 (40) 24 (54.5) 40 (48.2) 0.158 Alcohol consumption, n (%) 21 (36.2) 25 (33.3) 21 (47.7) 37 (44.6) 0.314 Comorbidity Hypertension, n (%) 7 (12.1) 9 (12) 10 (22.7) 13 (15.7) 0.390 Diabetes mellitus, n (%) 3 (5.2) 3 (4) 0 2 (2.4%) 0.285 Coronary heart disease, n (%) 2 (3.4) 2 (2.7) 2 (4.5) 3 (3.6) 0.457 Number of deaths, n (%) 0 2 (2.7) 1 (2.3) 16 (19.3) <0.001 HFRS-related complication Hemorrhage, n (%) 22 (37.90) 32 (42.70) 30 (68.20) 62 (74.70) <0.001 Secondary infection, n (%) 23 (39.70) 34 (45.30) 19 (43.20) 49 (59.00) 0.098 Hepatic injury, n (%) 25 (43.10) 40 (53.30) 23 (52.30) 61 (73.50) 0.013 Sepsis, n (%) 0 0 1 (2.30) 7 (8.40) 0.003 MODS, n (%) 0 0 0 11 <0.001 Arrhythmia, n (%) 0 5 (6.7) 5 (11.40) 6 (7.2) 0.026 Kidney rupture, n (%) 0 0 1 (2.30) 1 (1.2) 0.260 Hospital stay, days 10 (6) 10 (4) 13 (8.50) 15 (13) <0.001 Blood transfusion, n (%) 7 (12.10) 12 (16) 24 (54.50) 56 (67.50) <0.001 CRRT, n (%) 0 0 16 (36.40) 58 (69.90) <0.001