Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

Table 5

The diagnostic characteristics of tumor markers in lung adenocarcinoma (LAC) and lung squamous cell carcinoma (LSCC).

Parameters	Hazard ratio	AUC	Sensitivity	Specificity	NPV	PPV
LAC ()
CEA	1.34	0.85	61.8	92.2	37.0	97.0
CA125	1.00	0.69	40.6	91.3	27.2	95.0
CA15-3	1.03	0.72	30.2	97.1	25.3	97.7
CA19-9	1.00	0.58	19.8	94.2	22.2	93.3
CA 72-4	1.01	0.61	21.7	88.3	21.5	88.5
CYFRA21-1	1.43	0.79	61.6	86.4	35.3	94.9
SCC-Ag	1.03	0.48	8.5	96.1	20.3	90.0
LSCC ()
CEA	1.09	0.70	23.5	92.2	42.8	83.0
CA125	1.00	0.68	28.9	91.3	44.3	84.2
CA15-3	1.03	0.58	9.0	97.1	39.8	83.3
CA19-9	1.00	0.47	5.4	94.2	38.2	60.0
CA72-4	1.03	0.59	16.9	88.3	39.7	70.0
CYFRA21-1	2.26	0.93	88.6	86.4	82.4	91.3
SCC-Ag	2.28	0.78	39.8	96.1	49.7	94.3

value < 0.05.